Cytotoxic Geranylated Xanthones and O-Alkylated Derivatives of .ALPHA.-Mangostin
نویسندگان
چکیده
منابع مشابه
Cytotoxic geranylated xanthones and O-alkylated derivatives of alpha-mangostin.
Two new geranylated xanthones, 6-O-methylcowanin (4) and oliverixanthone (5), along with five known compounds, cowanin, rubraxanthone, cowaxanthone, cowanol, and beta-mangostin, have been isolated from the bark of Garcinia oliveri. For comparison of their biological activities, one mono- and seven di-O-alkylated alpha-mangostin derivatives were synthesized from alpha-mangostin. The structures o...
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Quercetin, a ubiquitous flavonol, represents a promising leading drug for development of new chemotherapeutic agents. However, its limited cytotoxicity to cancer cells hampers its clinical use. In order to obtain novel quercetin derivatives with superior cytotoxicity, seven alkylated quercetin derivatives were synthesized. Solubility of these derivatives was determined by turbidimetry. Cytotoxi...
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A new prenylated xanthone (1), named caloxanthone N, together with two known constituents, gerontoxanthone C (2) and 2-hydroxyxanthone (3), was isolated from the ethanolic extract of the twigs of Calophyllum inophyllum. Their structures were completely elucidated using a combination of 1D, 2D NMR techniques (COSY, HMQC, HMBC, and ROESY) and HR-ESI-MS analyses. Compounds 1 and 2 exhibited cytoto...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2009
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.57.830